Resumo Este estudo tem como objetivo analisar os atributos da Atenção Primária à Saúde (APS) abrangente a partir da atuação das equipes de Saúde da Família com foco nas doenças crônicas não transmissíveis. Pesquisa qualitativa realizada entre agosto de 2018 a julho de 2019, na APS de Vitória da Conquista, Bahia, com 40 profissionais de saúde, por meio de grupos focais e entrevistas. A partir da análise temática, os temas centrais corresponderam aos sete atributos da APS abrangente. Como resultados, as potencialidades do trabalho das equipes relacionaram-se com a priorização do acesso, ao amplo leque de serviços oferecidos e o reconhecimento da realidade comunitária/familiar. Destacaram-se obstáculos relacionados a oferta, acessibilidade e cobertura dos serviços, fragmentação na coordenação assistencial e informacional, dificuldades de desenvolvimento de práticas inclusivas com a família e etnicamente situadas, bem como na continuidade da assistência, notadamente para o contexto rural. Espera-se que os resultados apresentados possam confirmar a necessidade de investimentos e a instituição de processos sistemáticos de avaliação do trabalho das equipes de saúde da família, a fim de acompanhar a trajetória de consolidação da APS no contexto do Sistema Único de Saúde brasileiro.

Abstract This study aims to analyze the attributes of comprehensive Primary Health Care (PHC) based on the work of the family health teams focused on non-communicable chronic diseases. Qualitative research conducted from August 2018 to July 2019, in primary health care in Vitória da Conquista, Bahia, Brazil, with 40 health professionals, through interviews and focus groups. From the thematic analysis, the central themes were defined, corresponding to the seven attributes of comprehensive PHC. As a result, the potentials work of the family health teams was related to prioritizing access, the wide range of services offered and the recognition of the community and family reality. The study highlighted obstacles related to service provision, accessibility, coverage, care fragmentation and in information coordination, challenges in developing practices with the family, in practices ethnically situated, and continuity of care, notably for the rural context. It is expected that the results presented may confirm the need for investments and the institution of systematic evaluation processes regarding the work of family health teams, in order to follow the trajectory of PHC consolidation in the context of the Brazilian Unified Health System.Resumo: Este estudo tem como objetivo analisar os atributos da Atenção Primária à Saúde (APS) abrangente a partir da atuação das equipes de Saúde da Família com foco nas doenças crônicas não transmissíveis. Pesquisa qualitativa realizada entre agosto de 2018 a julho de 2019, na APS de Vitória da Conquista, Bahia, com 40 profissionais de saúde, por meio de grupos focais e entrevistas. A partir da análise temática, os temas centrais corresponderam aos sete atributos da APS abrangente. Como resultados, as potencialidades do trabalho das equipes relacionaram-se com a priorização do acesso, ao amplo leque de serviços oferecidos e o reconhecimento da realidade comunitária/familiar. Destacaram-se obstáculos relacionados a oferta, acessibilidade e cobertura dos serviços, fragmentação na coordenação assistencial e informacional, dificuldades de desenvolvimento de práticas inclusivas com a família e etnicamente situadas, bem como na continuidade da assistência, notadamente para o contexto rural. Espera-se que os resultados apresentados possam confirmar a necessidade de investimentos e a instituição de processos sistemáticos de avaliação do trabalho das equipes de saúde da família, a fim de acompanhar a trajetória de consolidação da APS no contexto do Sistema Único de Saúde brasileiro.

Abstract Drawing on premises from Comparative Literature, Cultural Studies and Translation Studies, this paper seeks to understand the cultural relations that played a significant part in shaping Clarice Lispector’s linguistic, cultural and translational identity (Bildung), intending to establish a dialogue between the novel The Hour of the Star (2020), first published in 1977, and Clarice’s translation of The Picture of Dorian Gray [O Retrato de Dorian Gray (2016)], penned by Clarice in 1974. Starting from her relative closeness to the Jewish imaginary to her knowledge of English, French and Spanish, we can understand Clarice as a cultural translator. Among the various cultural connections, we can trace inside Clarice’s novel, the issues concerning the possibilities and the limits of literary and visual representation allows us to read Clarice’s novel tracing a comparison with Wilde’s novel.

Résumé En partant des postulats de la Littérature Comparée, des Études Culturelles et des Études de Traduction, nous cherchons à comprendre des relations culturelles qui étaient significatives pour Clarice Lispector en termes de sa formation (Bildung) linguistique, identitaire, culturelle et de traduction, avec le but d’établir un dialogue entre le roman A hora da Estrela (2020), publié en 1977 et la traduction de The Picture of Dorian Gray [O Retrato de Dorian Gray (2016)], signée par Clarice en 1974. En commençant par sa relative proximité avec l’imaginaire juif, sa connaissance d’Anglais, Français et Espagnol, nous pouvons comprendre Clarice comme une traductrice culturel. Parmi plusieurs connexions que nous pouvons tracer dans le roman de Clarice, les questions qui concernent les possibilités et les limites de la représentation littéraire et visuel nous ont permis de le lire en comparaison avec le roman de Wilde.

Resumo Amparados nos pressupostos da Literatura Comparada, dos Estudos Culturais e dos Estudos da Tradução, procuramos compreender as relações culturais que formaram (Bildung) Clarice Lispector em termos de sua identidade linguística, cultural e tradutória, a fim de estudar a tradução do romance O retrato de Dorian Gray (2016), assinada por Clarice em 1974 em diálogo com a sua novela de 1977, A hora da estrela (2020). Partindo da sua relativa proximidade com o imaginário judaico ao seu conhecimento do inglês, francês e espanhol, podemos entender Clarice como uma tradutora cultural. Dentre as várias conexões culturais que pudemos traçar no interior da novela de Clarice, as questões relativas às possibilidades e aos limites da representação literária e visual nos permitem lê-la em comparação com o romance de Wilde.

ABSTRACT The use of echocardiography by physicians who are not echocardiographers has become common throughout the world across highly diverse settings where the care of acutely ill patients is provided. Echocardiographic evaluation performed in a point-of-care manner can provide relevant information regarding the mechanism of causes of shock, for example, increasing the rates of correct diagnosis and allowing for faster informed decision-making than through evaluation methods. Considering that the accurate diagnosis of life-threatening situations is essential for professionals working with acutely ill patients, several international associations recommend that physicians responsible for critically ill patients acquire and develop the ability to perform bedside ultrasound examinations, including echocardiographic examinations. However, there is no consensus in the literature regarding which specific applications should be included in the list of skills for nonechocardiographer physicians. Taking into account the multiplicity of applications of echocardiography in different scenarios related to acutely ill patients; the differences in the published protocols, with regard to both the teaching methodology and competence verification; and the heterogeneity of training among highly diverse specialties responsible for their care at different levels, this consensus document aimed to reflect the position of representatives of related Brazilian medical societies on the subject and may thus serve as a starting point both for standardization among different specialties and for the transmission of knowledge and verification of the corresponding competencies.

RESUMO O emprego da ecocardiografia por médicos não ecocardiografistas tem se tornado comum em todo o mundo nos mais diversos ambientes em que se dá o cuidado do paciente agudamente doente. A avaliação ecocardiográfica realizada de forma point-of-care pode fornecer informações pertinentes em relação ao mecanismo das causas de choque, por exemplo, incrementando as taxas de diagnóstico correto e possibilitando a tomada de decisão fundamentada de forma mais rápida do que por meio dos métodos tradicionais de avaliação. Considerando que o diagnóstico preciso de situações ameaçadoras à vida é indispensável a profissionais atuando junto a pacientes agudamente enfermos, diversas entidades associativas internacionais recomendam que médicos responsáveis por pacientes gravemente doentes devam adquirir e desenvolver a habilidade para realizar exames ultrassonográficos à beira do leito, inclusive ecocardiográficos. Entretanto, não há consenso na literatura acerca de quais aplicações específicas devam compor o rol de habilidades do médico não ecocardiografista. Levando-se em consideração a multiplicidade de aplicações da ecocardiografia em diversos cenários relativos ao paciente agudamente enfermo; as diferenças nos protocolos publicados, tanto no que diz respeito à metodologia de ensino como de verificação de competências, bem como a heterogeneidade da formação entre as mais diversas especialidades responsáveis pelo seu cuidado em diferentes níveis, este documento de consenso teve o objetivo de refletir o posicionamento de representantes de sociedades médicas brasileiras afins acerca do tema, podendo, assim, servir de ponto de partida para a uniformização entre diferentes especialidades, bem como para a transmissão de conhecimento e a verificação das competências correspondentes.

ABSTRACT Echocardiography in critically ill patients has become essential in the evaluation of patients in different settings, such as the hospital. However, unlike for other matters related to the care of these patients, there are still no recommendations from national medical societies on the subject. The objective of this document was to organize and make available expert consensus opinions that may help to better incorporate echocardiography in the evaluation of critically ill patients. Thus, the Associação de Medicina Intensiva Brasileira, the Associação Brasileira de Medicina de Emergência, and the Sociedade Brasileira de Medicina Hospitalar formed a group of 17 physicians to formulate questions relevant to the topic and discuss the possibility of consensus for each of them. All questions were prepared using a five-point Likert scale. Consensus was defined a priori as at least 80% of the responses between one and two or between four and five. The consideration of the issues involved two rounds of voting and debate among all participants. The 27 questions prepared make up the present document and are divided into 4 major assessment areas: left ventricular function, right ventricular function, diagnosis of shock, and hemodynamics. At the end of the process, there were 17 positive (agreement) and 3 negative (disagreement) consensuses; another 7 questions remained without consensus. Although areas of uncertainty persist, this document brings together consensus opinions on several issues related to echocardiography in critically ill patients and may enhance its development in the national scenario.

RESUMO A ecocardiografia do paciente grave tem se tornado fundamental na avaliação de pacientes em diferentes cenários e ambientes hospitalares. Entretanto, ao contrário de outras áreas relativas ao cuidado com esses pacientes, ainda não existem recomendações de sociedades médicas nacionais acerca do assunto. O objetivo deste documento foi organizar e disponibilizar opiniões de consenso de especialistas que possam auxiliar a melhor incorporação dessa técnica na avaliação de pacientes graves. Dessa forma, a Associação de Medicina Intensiva Brasileira, a Associação Brasileira de Medicina de Emergência e a Sociedade Brasileira de Medicina Hospitalar compuseram um grupo de 17 médicos para formular questões pertinentes ao tópico e debater a possibilidade de consenso de especialistas para cada uma delas. Todas as questões foram elaboradas no formato de escala Likert de cinco pontos. Consenso foi definido, a priori, como um somatório de, ao menos, 80% das respostas entre um e dois ou entre quatro e cinco. A apreciação das questões envolveu dois ciclos de votação e debate entre todos os participantes. As 27 questões elaboradas compõem o presente documento e estão divididas em 4 grandes áreas de avaliação: da função ventricular esquerda; da função ventricular direita; diagnóstica dos choques e hemodinâmica. Ao fim do processo, houve 17 consensos positivos (concordância) e 3 negativos (discordância); outras 7 questões persistiram sem consenso. Embora persistam áreas de incerteza, este documento reúne opiniões de consenso para diversas questões relativas à ecocardiografia do paciente grave e pode potencializar seu desenvolvimento no cenário nacional.

ABSTRACT Objective To verify the involvement of the endocannabinoid system in the immunomodulatory profile of stem cells from human exfoliated deciduous teeth, in the presence or absence of TNF-α, and agonist and antagonists of CB1 and CB2. Methods Stem cells from human exfoliated deciduous teeth were cultured in the presence or absence of an agonist, anandamide, and two antagonists, AM251 and SR144528, of CB1 and CB2 receptors, with or without TNF-α stimulation. For analysis of immunomodulation, surface molecules linked to immunomodulation, namely human leukocyte antigen-DR isotype (HLA-DR), and programmed death ligands 1 (PD-L1) and 2 (PD-L2) were measured using flow cytometry. Results The inhibition of endocannabinoid receptors together with the proinflammatory effect of TNF-α resulted in increased HLA-DR expression in stem cells from human exfoliated deciduous teeth, as well as, in these cells acquiring an anti-inflammatory profile by enhancing the expression of PD-L1 and PD-L2. Conclusion Stem cells from human exfoliated deciduous teeth respond to the endocannabinoid system and TNF-α by altering key immune response molecules.

Abstract Ankle sprain is the most common injury in the lower limbs of physically active individuals, and one of its complications is chronic ankle instability (CAI), for which Kinesio Taping (KT) can be an alternative treatment. The aim of this study was to compare two treatment protocols with KT at different tensions on postural control, dynamic balance, agility and instability in individuals with chronic ankle instability. This is a randomized clinical trial in which postural control was evaluated through the force platform, agility by the side Hop Test, dynamic balance by the modified Star Excursion balance Test, and application of the Cumberland Ankle Tool Instability and Foot and Ankle Outcome Score to assess self-reported instability and functional instability. An initial assessment was conducted, followed by 5 weeks of intervention with weekly applications of KT, and one week after the completion of the intervention, a reassessment was performed. 21 participants were distributed to the group KT with tension (KTT: n=11) and the group KT without tension (KTWT: n=10). KT improves postural control (anteroposterior velocity: p=0.006 and mediolateral: p<0.001; anteroposterior frequency: p<0.001 and mediolateral: p=0.043 of the area of the center of pressure), dynamic balance (p< 0.001), agility (p=0.001) and feeling of instability in individuals with ICT (p=0.001) for both groups. Only one variable, sports category of the FAOS-FOOT questionnaire showed significant change (p=0.008). KT, with or without tension, is able to improve postural control, balanced balance, postural control, and feelings of instability in young adults with ICT.

Resumo A entorse de tornozelo, uma lesão comum em indivíduos fisicamente ativos, frequentemente resulta em uma complicação chamada instabilidade crônica do tornozelo (ICT). A Kinesio Taping (KT) pode ser uma alternativa de tratamento para essa condição. O objetivo deste estudo foi comparar dois protocolos de tratamento com KT em diferentes tensões no controle postural, equilíbrio dinâmico, agilidade e instabilidade em indivíduos com instabilidade crônica do tornozelo. Trata-se de um ensaio clínico randomizado no qual o controle postural foi avaliado por meio da plataforma de força, a agilidade pelo side Hop Test, o equilíbrio dinâmico pelo Star Excursion balance Test modificado e para avaliar instabilidade funcional e autorrelatada aplicou-se o Foot and Ankle Outcome Score e o Cumberland Ankle Tool Instability. Foi realizada uma avaliação inicial, seguida de 5 semanas de intervenção com aplicações semanais de KT, e uma semana após o término da intervenção, foi realizada uma reavaliação. 21 participantes foram distribuídos para o grupo KT com tensão (KTT: n=11) e o grupo KT sem tensão (KTWT: n=10). KT melhora o controle postural (velocidade ântero-posterior: p=0,006 e médio-lateral: p<0,001; frequência anteroposterior: p<0,001 e médio-lateral: p=0,043 da área do centro de pressão), equilíbrio dinâmico (p<0,001), agilidade (p=0,001) e sensação de instabilidade em indivíduos com ICT (p=0,001) para ambos os grupos. Apenas uma variável, categoria esportiva, do questionário FAOS-FOOT apresentou alteração significativa (p=0,008). O KT, com ou sem tensão, é capaz de melhorar o controle postural, o equilíbrio equilibrado, o controle postural e a sensação de instabilidade em adultos jovens com ICT.

SUMMARY OBJECTIVE: This study aimed to assess older people’s knowledge of the purpose of drugs prescribed at medical appointments in primary care units and the possible factors related to their level of knowledge about their medications. METHODS: This was a cross-sectional study conducted in 22 basic health units in Brazil. Patients aged ≥60 years were included in this study (n=674). Knowledge of prescribed medications was assessed by comparing the responses to the questionnaire and the medication and prescription information. Multivariate analyses were conducted using the Poisson regression with robust variance. RESULTS: The mean age of the sample was 70.1 (standard deviation: ±7.1) years. Among 674 patients, 272 (40.4%) did not know the indication of at least 1 of their prescribed drugs; among them, 78 (11.6%) did not know the indication of any of their prescribed drugs. In the final multivariate analysis, polypharmacy, illiteracy, and cognitive impairment were found to be associated with misunderstanding the purpose of at least one prescribed drug. Moreover, illiteracy and cognitive impairment were associated with a greater misunderstanding of the purpose of all prescribed drugs. CONCLUSIONS: In the studied sample, patients demonstrated a high rate of misunderstanding of the purpose of prescribed drugs. Therefore, it is necessary for health services and professionals to implement strategies that increase the quality of the guidance and instructions given to older people in order to promote adherence to treatment.

ABSTRACT BACKGROUND: Physician and patient-related characteristics can influence prescription of medications to older patients within primary healthcare. Use of Brazilian criteria may indicate the real prevalence of prescription of potentially inappropriate medications to this population. OBJECTIVES: To evaluate prescription of potentially inappropriate medications to older patients within primary care and identify patient-related and prescribing physician-related factors. DESIGN AND SETTING: This cross-sectional study was conducted in 22 public primary care facilities in Brazil, among older people (≥ 60 years) who were waiting for medical consultations. METHODS: Interviews were conducted before and after the medical consultations. If the patient received a medical prescription at the consultation, all the drugs prescribed and the physician's medical council registration number were recorded. Prevalence ratios were estimated to ascertain the magnitude of prescription of potentially inappropriate medications, along with patient and physician-related factors associated with such prescription. RESULTS: In total, 417 older patients were included; 45.3% had received ≥ 1 potentially inappropriate medication, and 86.8% out of 53 physicians involved had prescribed ≥ 1 potentially inappropriate medication. The strongest patient-related factor associated with higher prevalence of prescription of potentially inappropriate medications was polypharmacy. Among physician-related factors, the number of patients attended, number of prescriptions and length of medical practice < 10 years were positively associated with prescription of potentially inappropriate medications. CONCLUSIONS: High prevalence of prescription of potentially inappropriate medications was observed. Physician-related characteristics can influence prescription of medications to older people within primary healthcare. This suggests that there is a need for interventions among all physicians, especially younger physicians.

Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.

Abstract This study evaluated the ability of resistance training (RT) of moderate intensity to promote vascular changes in insulin-induced vasodilation in healthy animals. Wistar rats were divided into two groups: control (CON) and trained (eight weeks of training, performing 3 sets with 10 repetitions at 60% of maximum intensity). Forty-eight hours after the last session of the RT, the animals were sacrificed and vascular reactivity to insulin in the absence and presence of LY294002 (phosphatidylinositol 3-kinase inhibitors (PI3K), L-NAME (nitric oxide synthase (NOS) inhibitors) and BQ123 (endothelin A antagonist (ET-A) receptor). In addition, phenylephrine (Phe)-induced vasoconstriction in the absence and presence of L-NAME was also evaluated. The RT group showed greater vasodilation in maximal response compared to the CON group. After PI3K inhibition, vasodilation was reduced in both groups. However, when the NOS participation was evaluated, the RT group showed contraction in relation to the CON group, which was abolished by BQ123. In addition, the RT group had an increase in nitrite levels compared to the CON group. When the Phe response was evaluated, there was a reduction in tension in the RT group compared to the CON group. The results suggest that RT improves vascular reactivity.

Abstract Peanut is a crop of the Kayabi tribe, inhabiting the Xingu Indigenous Park, Brazil. Morphological analysis of Xingu accessions showed variation exceeding that described for cultivated peanuts. This raised questions as to the origin of the Xingu accessions: are they derived from different species, or is their diversity a result of different evolutionary and selection processes? To answer these questions, cytogenetic and genotyping analyses were conducted. The karyotypes of Xingu accessions analyzed are very similar to each other, to an A. hypogaea subsp. fastigiata accession and to the wild allotetraploid A. monticola. The accessions share the number and general morphology of the chromosomes; DAPI+ bands; 5S and 45S rDNA loci distribution and a high genomic affinity with A. duranensis and A. ipaënsis genomic probes. However, the number of CMA3+ bands differs from those determined for A. hypogaea and A. monticola, which are also different from each other. SNP genotyping grouped all Arachis allotetraploids into four taxonomic groups: Xingu accessions were closer to A. monticola and A. hypogaea subsp. hypogaea. Our data suggests that the morphological diversity within these accessions is not associated with a different origin and can be attributed to morphological plasticity and different selection by the Indian tribes.

ABSTRACT Objective: To know the experience of family members in the care of people with depression. Method: Thematic Oral History that uses a hybrid methodology performed in a CAPS III (Psychosocial Care Center) in the capital of a state in southern Brazil, with data collected between January and July 2019. Family members of individuals undergoing treatment for depression in the CAPS III were included in the study and those family members who had no time to participate in the study and those who were underage were excluded. Four collaborators participated in the study. Results: Four themes were revealed: Understanding the disease and the historical path in health services; the impact of depression on the physical health and on the financial situation of family members; the emotional impact of depression on family relationships; Religiosity and spirituality as elements for coping with the disease. Conclusion: Depression makes patients’ families vulnerable and affects their lives. The study suggests foci for interventions by health professionals with family members, adds knowledge on depression and collaborates with further studies.

RESUMEN: Objetivo: conocer la vivencia de los familiares en el cuidado de la persona con depresión. Método: Historia Oral Temática Híbrida, cuyo sitio fue un Centro de Atención Psicosocial III de una capital del sur de Brasil, con obtención de datos entre enero y julio de 2019. Se añadió el familiar de la persona en tratamiento para depresión en el CAPS III y se excluyeron los que tenían indisponibilidad de tiempo, además de familiar menor de edad. Participaron cuatro empleados. Resultados: emergieron cuatro temas: El entendimiento acerca de la enfermedad y la trayectoria en los servicios de salud; El impacto de la depresión en la salud física y en la cuestión financiera de los familiares; El impacto emocional de la depresión en las relaciones familiares; La religiosidad y la espiritualidad como elementos para el afrontamiento de la enfermedad. Conclusión: la depresión vuelve vulnerable y afecta la vida del familiar. La investigación sugestiona focos de intervención de los profesionales de salud con los familiares, añade conocimiento sobre la depresión y colabora para nuevas investigaciones.

RESUMO Objetivo: conhecer a vivência dos familiares no cuidado da pessoa com depressão. Método: História Oral Temática Híbrida, tendo como local um CAPS III de uma capital do sul do Brasil, com coleta de dados entre janeiro e julho de 2019. Incluiu-se o familiar da pessoa em tratamento para depressão no CAPS III e excluídos os que tinham indisponibilidade de tempo, e familiar menor de idade. Participaram quatro colaboradores. Resultados: revelaram-se quatro temas: O entendimento sobre a doença e a trajetória nos serviços de saúde; O impacto da depressão na saúde física e na questão financeira dos familiares; O impacto emocional da depressão nas relações familiares; A religiosidade e a espiritualidade como elementos para o enfrentamento da doença. Conclusão: a depressão vulnerabiliza e afeta a vida do familiar. A pesquisa sugestiona focos de intervenção dos profissionais de saúde com os familiares, agrega conhecimento sobre a depressão e colabora para novas pesquisas.

Abstract This study evaluated whether resistance training (RT) could prevent glucocorticoid-induced vascular changes. Wistar rats were divided into groups: control (CO), dexamethasone (DEX), and Dexamethasone+RT (DEX+RT). On the eighth week, dexamethasone was administered in the DEX and DEX+RT groups. Thereafter, the animals were sacrificed and blood samples were used to assess the lipid profile, glucose and insulin. Vascular reactivity to insulin and phenylephrine (Phe) were evaluated. The DEX+RT group presented an improvement in the lipid profile, fasting glucose, and insulin levels compared to the DEX group. In addition, vasodilation was reduced in the DEX group compared to the CO group, and was increased in the DEX+RT group. After inhibition of phosphatidylinositol 3-kinase, DEX group showed contraction, in which it was in the DEX + RT group. When nitric oxide synthase (NOS) participation was evaluated, the DEX group presented a contraction compared to the CO group, with no contractile effect in the DEX+RT group. Moreover, vasoconstriction caused by NOS inhibition was abolished by BQ123 (endothelin receptor antagonist). In respect Phe response, there was an increase in tension in the DEX group compared to the CO group, being reduced in the DEX+RT group. The results suggest that RT prevented damage to vascular reactivity.

RESUMO Objetivo Verificar a ocorrência de resistência a fármacos antituberculose e a associação com características sociodemográficas e clínicas de pacientes de um hospital referência. Métodos Estudo transversal, com dados de pacientes que tiveram a cultura de micobactérias identificada e o respectivo perfil de sensibilidade aos antimicrobianos definido (junho de 2014 a fevereiro de 2016). Foram realizados a análise estatística descritiva e o teste exato de Fisher, para comparação de proporções. Resultados O estudo envolveu 104 pacientes, e todos tiveram resultados para Mycobacterium tuberculosis . A baciloscopia atingiu alta positividade (93,3%), e 15 pacientes (14,4%) apresentaram linhagens resistentes, sendo 6 (5,6%) multirresistentes. As características sociodemográficas e clínicas não foram associadas à resistência. Conclusão A pesquisa permitiu conhecer melhor o perfil dos pacientes com tuberculose e constitui ferramenta para elaboração de políticas públicas específicas. Os pacientes diagnosticados com tuberculose resistente devem ser submetidos à maior supervisão.

ABSTRACT Objective To determine the occurrence of anti-tuberculosis drug resistance and its association with sociodemographic and clinical characteristics of patients in a referral hospital. Methods This was a cross-sectional study based on data from patients who had mycobacterial culture identified and defined antimicrobials sensitivity profile (June 2014 to February 2016). The descriptive statistical analysis and Fisher’s exact test were used to compare proportions. Results The study included 104 patients who had positive results for Mycobacterium tuberculosis . Bacilloscopy had high positivity (93.3%). A total of 15 patients (14.4%) had resistant strains and six (5.6%) multidrug-resistant. The sociodemographic and clinical characteristics were not related with resistance. Conclusion This study contributed to further the understandings about the tuberculosis patients’ profile, the study also served as a tool for development of specific public policies. Patients diagnosed with resistant tuberculosis must be under greater supervision.